Personal model‐assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD

Abstract To elucidate the molecular mechanisms underlying non‐alcoholic fatty liver disease (NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis (HS). We obtained experimental data on lipoprotein fluxes and used these individual measurements as personalized constraints of a he...

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Hauptverfasser:	Adil Mardinoglu, Elias Bjornson, Cheng Zhang, Martina Klevstig, Sanni Söderlund, Marcus Ståhlman, Martin Adiels, Antti Hakkarainen, Nina Lundbom, Murat Kilicarslan, Björn M Hallström, Jesper Lundbom, Bruno Vergès, Peter Hugh R Barrett, Gerald F Watts, Mireille J Serlie, Jens Nielsen, Mathias Uhlén, Ulf Smith, Hanns‐Ulrich Marschall, Marja‐Riitta Taskinen, Jan Boren
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer Nature 2017-03-01
Schriftenreihe:	Molecular Systems Biology
Schlagworte:	glutathione NAFLD personalized genome‐scale metabolic modeling serine
Online-Zugang:	https://doi.org/10.15252/msb.20167422
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