Integrated ATAC-seq and RNA-seq analysis identifies Grid2 and Reln as potential regulatory genes in migraine pathophysiology

Abstract Background Migraine pathophysiology involves epigenetic mechanisms, but key molecular regulators remain poorly defined. This study aimed to elucidate these mechanisms using a comprehensive multi-omics approach. Methods We established a nitroglycerin (NTG)-induced migraine-like mouse model....

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Detalhes bibliográficos

Principais autores:	Fei Wang, Chenlu Zhu, Fei Shen, Yuanmei Pan, Xianguo Jiang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-12-01
coleção:	The Journal of Headache and Pain
Assuntos:	ATAC-seq RNA-seq Migraine-like hypersensitivity Synaptic pathway
Acesso em linha:	https://doi.org/10.1186/s10194-025-02228-4
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