Circadian rhythms in pediatric high-grade gliomas may contribute to treatment efficacy

Abstract Pediatric high-grade gliomas (pHGG) are highly invasive with poor survival outcomes. Timing of Temozolomide administration has been shown to affect survival of adult patients with glioblastoma. We investigated whether pHGGs express circadian genes rhythmically and whether underlying rhythms...

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Autors principals:	Ella A. Nettnin, Cesar A. Garcia, Fudhial F. Sayed, Ethan Schonfeld, Thien Nguyen, Maria Isabel Barros Guinle, Claudia K. Petritsch, Erin M. Gibson, Laura M. Prolo
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-08-01
Col·lecció:	Scientific Reports
Matèries:	Circadian rhythms Chronotherapy Pediatric high-grade glioma Pediatric low-grade glioma Pediatric glioblastoma Circadian medicine
Accés en línia:	https://doi.org/10.1038/s41598-025-17461-9
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