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Stops making sense: translational trade-offs and stop codon reassignment

<p>Abstract</p> <p>Background</p> <p>Efficient gene expression involves a trade-off between (i) premature termination of protein synthesis; and (ii) readthrough, where the ribosome fails to dissociate at the terminal stop. Sense codons that are similar in sequence to stop codons are more susceptible...

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Autores principales: Elgar Greg S, Lichtenstein Conrad P, Cotton James A, Johnson Louise J, Nichols Richard A, Polly p David, Le Comber Steven C
Formato: Artigo
Lenguaje:Inglês
Publicado: BMC 2011-07-01
Colección:BMC Evolutionary Biology
Acceso en línea:http://www.biomedcentral.com/1471-2148/11/227
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