Fulvestrant-induced cell death and proteasomal degradation of estrogen receptor α protein in MCF-7 cells require the CSK c-Src tyrosine kinase.

Fulvestrant is a representative pure antiestrogen and a Selective Estrogen Receptor Down-regulator (SERD). In contrast to the Selective Estrogen Receptor Modulators (SERMs) such as 4-hydroxytamoxifen that bind to estrogen receptor α (ERα) as antagonists or partial agonists, fulvestrant causes protea...

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Détails bibliographiques

Auteurs principaux:	Wei-Lan Yeh, Keiko Shioda, Kathryn R Coser, Danielle Rivizzigno, Kristen R McSweeney, Toshi Shioda
Format:	Artigo
Langue:	Inglês
Publié:	Public Library of Science (PLoS) 2013-01-01
Collection:	PLoS ONE
Accès en ligne:	http://europepmc.org/articles/PMC3617152?pdf=render
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