Clonally expanded effector CD4+ cytotoxic T lymphocytes are associated with severe neurological adverse events after immune checkpoint inhibitor therapy

Background Immune checkpoint inhibitor (ICI) therapies present a pillar of modern cancer therapy but can cause neurological immune-related adverse events (n-irAEs), of which up to 35% are severe or even fatal. However, the detailed immunological mechanisms and risk factors underlying n-irAEs remain...

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Principais autores:	Matthias Endres, Samuel Knauss, Leif S. Ludwig, Leonie Müller-Jensen, Wolfgang Boehmerle, Petra Huehnchen, Ambre Manon Giguelay, Patrick Maschmeyer, Christian Schinke, Smilla K Maierhof, Natasha Nambiar, Manpreet Meyer
Format:	Artigo
Jezik:	Inglês
Izdano:	BMJ Publishing Group 2025-10-01
Serija:	Journal for ImmunoTherapy of Cancer
Online dostop:	https://jitc.bmj.com/content/13/10/e012350.full
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