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Opposing roles for myeloid and smooth muscle cell STING in pulmonary hypertension

There is an emerging role for stimulator of interferon genes (STING) signaling in pulmonary hypertension (PH) development. Related to this, prior research has demonstrated the relevance of immune checkpoint protein programmed death ligand 1 (PD-L1) expression by immunoregulatory myeloid cells in PH....

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Principais autores: Ann T. Pham, Shiza Virk, Aline C. Oliveira, Matthew D. Alves, Chunhua Fu, Yutao Zhang, Jimena Alvarez-Castanon, Brian B. Lee, Keira L. Lee, Radwan Mashina, Katherine E. Ray, Patrick Donabedian, Elnaz Ebrahimi, Harsh Patel, Reeha Patel, Duncan Lewis, Zhiguang Huo, Harry Karmouty-Quintana, Li Chen, Lei Jin, Andrew J. Bryant
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical investigation 2025-07-01
coleção:JCI Insight
Assuntos:
Pulmonology
Vascular biology
Acesso em linha:https://doi.org/10.1172/jci.insight.184792
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