Lipidomic analysis links mycobactin synthase K to iron uptake and virulence in M. tuberculosis.

The prolonged survival of Mycobacterium tuberculosis (M. tb) in the host fundamentally depends on scavenging essential nutrients from host sources. M. tb scavenges non-heme iron using mycobactin and carboxymycobactin siderophores, synthesized by mycobactin synthases (Mbt). Although a general mechani...

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Autors principals:	Cressida A Madigan, Amanda Jezek Martinot, Jun-Rong Wei, Ashoka Madduri, Tan-Yun Cheng, David C Young, Emilie Layre, Jeffrey P Murry, Eric J Rubin, D Branch Moody
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2015-03-01
Col·lecció:	PLoS Pathogens
Accés en línia:	http://europepmc.org/articles/PMC4376628?pdf=render
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