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MMP12 knockout prevents weight and muscle loss in tumor-bearing mice

Abstract Background Colorectal cancer is a malignant gastrointestinal cancer, in which some advanced patients would develop cancer cachexia (CAC). CAC is defined as a multi-factorial syndrome characterized by weight loss and muscle loss (with or without fat mass), leading to progressive dysfunction,...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Lingbi Jiang, Mingming Yang, Shihui He, Zhengyang Li, Haobin Li, Ting Niu, Dehuan Xie, Yan Mei, Xiaodong He, Lili Wei, Pinzhu Huang, Mingzhe Huang, Rongxin Zhang, Lijing Wang, Jiangchao Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2021-12-01
Schriftenreihe:BMC Cancer
Schlagworte:
MMP12
ApcMin/+
Macrophage
IL-6
Cancer cachexia
Colorectal cancer
Online-Zugang:https://doi.org/10.1186/s12885-021-09004-y
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