Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation

Multiple myeloma (MM) is characterized by excessive aggregation of B-cell-derived malignant plasma cells in the hematopoietic system of bone marrow. Previously, we synthesized an innovative molecule named dihydrocelastrol (DHCE) from celast...

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Principais autores:	Jin Shuhan, Li Bo, Zhang Bibo, Gao Xuejie, Jia Xinyan, Xu Li, Chang Shuaikang, Hu Ke, Wang Guanli, Xu Zhijian, Zhang Ting, Song Dongliang, Yang Guang, Wu Xiaosong, Zhu Huabin, Huang Cheng, Lu Yumeng, Shi Jumei, Zhu Weiliang, Chen Gege
Format:	Artigo
Jezik:	Inglês
Izdano:	China Science Publishing & Media Ltd. 2023-11-01
Serija:	Acta Biochimica et Biophysica Sinica
Teme:	dihydrocelastrol multiple myeloma JAK2/STAT3 PSMB5 bortezomib resistance
Online dostop:	https://www.sciengine.com/doi/10.3724/abbs.2023260
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