Prevention and management of diarrhea associated with naldemedine among patients receiving opioids: a retrospective cohort study

Abstract Background Naldemedine, a novel peripherally-acting mu-opioid receptor antagonist, has improved opioid-induced constipation in randomized controlled trials. The most frequent adverse event of naldemedine is diarrhea, which can cause abdominal pain and often leads to treatment discontinuatio...

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Detalhes bibliográficos

Principais autores:	Yusuke Takagi, Gakuji Osawa, Yoriko Kato, Eri Ikezawa, Chika Kobayashi, Etsuko Aruga
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-01-01
coleção:	BMC Gastroenterology
Assuntos:	Adverse events Diarrhea Naldemedine Opioid-induced constipation Peripherally-acting mu-opioid receptor antagonist
Acesso em linha:	https://doi.org/10.1186/s12876-020-1173-z
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