Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of ⁶⁸Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics

High kidney uptake is a common feature of peptide-based radiopharmaceuticals, leading to reduced detection sensitivity for lesions adjacent to kidneys and lower maximum tolerated therapeutic dose. In this study, we evaluated if the Met-Val-Lys (MVK) linker could be used to lower kidney uptake of <su...

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Principais autores:	Shreya Bendre, Zhengxing Zhang, Hsiou-Ting Kuo, Julie Rousseau, Chengcheng Zhang, Helen Merkens, Áron Roxin, François Bénard, Kuo-Shyan Lin
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2020-08-01
Serier:	Molecules
Fag:	radiopharmaceuticals kidney uptake cleavable linkers neutral endopeptidase (NEP) renal brush border enzymes prostate-specific membrane antigen (PSMA)
Online adgang:	https://www.mdpi.com/1420-3049/25/17/3854
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