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HIF-2α accumulation in human monocytes upon transfer of hypoxia-associated miRNAs via plasma-derived small extracellular vesicles from head and neck cancer patients

Hypoxia is an important hallmark of the tumor microenvironment (TME) in solid tumors and is closely associated with resistance to radiotherapy and a poorer clinical outcome. Tumor-associated plasma-derived small extracellular vesicles (sEVs) have gained increasing attention as an important regulator...

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Main Authors: Marie-Nicole Theodoraki, Linda Hofmann, Helen Bauer, Jonas Fleckner, Reinhard Depping, Christian Idel, Kirstin Plötze-Martin, Zuzana Penxova, Dirk Rades, Thomas K. Hoffmann, Karl-Ludwig Bruchhage, Ralph Pries
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2026-01-01
Series:Frontiers in Oncology
Subjects:
HIF-2α
HNSCC
hypoxia
liquid biomarker
miRNA
monocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1701388/full
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