Proteolytic biomarkers are related to prognosis in COPD- report from a population-based cohort

Abstract Background The imbalance between proteases and anti-proteases is considered to contribute to the development of COPD. Our aim was to evaluate the protease MMP-9, the antiprotease TIMP-1 and the MMP-9/TIMP-1-ratio as biomarkers in relation to prognosis. Prognosis was assessed as lung functio...

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Autori principali:	Robert Linder, Eva Rönmark, Jamshid Pourazar, Annelie F. Behndig, Anders Blomberg, Anne Lindberg
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2018-04-01
Serie:	Respiratory Research
Soggetti:	Chronic obstructive pulmonary disease (COPD) Matrix metalloproteinases Tissue inhibitor of metalloproteinases Mortality Spirometry
Accesso online:	http://link.springer.com/article/10.1186/s12931-018-0772-5
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