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The soluble epoxide hydrolase inhibitor TPPU alleviates Aβ-mediated neuroinflammatory responses in Drosophila melanogaster and cellular models of alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is a common neurodegenerative disease, and its pathogenesis is closely associated with neuroinflammation. The control of neuroinflammation in AD is the focus of current research. soluble epoxide hydrolase (sEH) protein is increased in the brain tissues of...

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Gardado en:
Principais autores: Xiaowen Sun, Hongxiang Liu, Wei Li, Lin Li, Qian Tian, Qingyang Cao, Yun Meng, Yan Shen, Fengyuan Che, Joanna C. Chiu, Jixu Yu, Bruce D. Hammock
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2025-06-01
Series:Journal of Inflammation
Assuntos:
Alzheimer’s disease
Neuroinflammation
TPPU
Neuroprotection
Drosophila melanogaster
Cell
Acceso en liña:https://doi.org/10.1186/s12950-025-00449-7
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