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Elucidation of puberulic acid–induced nephrotoxicity using stem cell-based kidney organoids

Abstract Recent cases of acute kidney injury (AKI) in Japan have been linked to Beni-koji CholesteHelp supplements, with puberulic acid identified as a potential nephrotoxic contaminant. To address the need for a reliable in vitro nephrotoxicity testing platform, we developed a screening model using...

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主要な著者: Hiroyuki Nakanoh, Kenji Tsuji, Naruhiko Uchida, Kazuhiko Fukushima, Soichiro Haraguchi, Shinji Kitamura, Jun Wada
フォーマット: Artigo
言語:Inglês
出版事項: Nature Portfolio 2025-11-01
シリーズ:Scientific Reports
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オンライン・アクセス:https://doi.org/10.1038/s41598-025-26155-1
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