Generation and in vivo validation of an IL-12 fusion protein based on a novel anti-human FAP monoclonal antibody

Background In this study, we describe the generation of a fully human monoclonal antibody (named ‘7NP2’) targeting human fibroblast activation protein (FAP), an antigen expressed in the microenvironment of different types of solid neoplasms.Methods 7NP2 was isolated from a synthetic antibody phage d...

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Detalles Bibliográficos

Principais autores:	Michael Weller, Tobias Weiß, Giampaolo Tortora, Dario Neri, Emanuele Puca, Carmine Carbone, Geny Piro, Lisa Nadal, Frederik Peissert, Abdullah Elsayed, Thomas Look, Mattia Matasci, Nicholas Favalli, Riccardo Corbellari, Cesare Di Nitto, Eleonora Prodi, Chiara Libbra, Simone Galeazzi, Claudiopietro Carotenuto, Cornelia Halin, Roberto De Luca
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMJ Publishing Group 2022-09-01
Series:	Journal for ImmunoTherapy of Cancer
Acceso en liña:	https://jitc.bmj.com/content/10/9/e005282.full
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