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Dendrobium alkaloids decrease Aβ by regulating α- and β-secretases in hippocampal neurons of SD rats

Background Alzheimer’s disease (AD) is the primary cause of dementia in the elderly. The imbalance between production and clearance of amyloid β (Aβ) is a very early, often initiating factor in AD. Dendrobium nobile Lindl. alkaloids (DNLA) extracted from a Chinese medicinal herb, which have been sho...

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Principais autores: Juan Huang, Nanqu Huang, Minghui Zhang, Jing Nie, Yunyan Xu, Qin Wu, Jingshan Shi
Format: Artigo
Sprog:Inglês
Udgivet: PeerJ Inc. 2019-09-01
Serier:PeerJ
Fag:
Dendrobium nobile Lindl. alkaloids
α-secretase
Hippocampal neurons
β-secretase
γ-secretase
Online adgang:https://peerj.com/articles/7627.pdf
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