Rare cases in two Chinese MEN2A families with RET C634Y germline mutation—a homozygous female patient and heterozygous identical twins: a systematic review of literature

BackgroundGermline RET-p.C634Y heterozygous mutations are predominant in MEN2A, but homozygous cases and MEN2A-affected identical twins remain poorly characterized.SummaryWe report two MEN2A families—a homozygous female patient and heterozygous male twins, all with RET-p.C634Y mutations and classic...

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Главные авторы:	Xiao-Ping Qi, Yu-Ting Weng, Zhen-Yu Chen, Mei-Xian Zhang, Xiao-Ling Yang, Zhi-Lie Cao, Xue-Xing Zhang, Wen-Bo Zhu, Hong-Yuan Yu, Wei-Ying Chen, Ji-Ya Chen, Fei-Ping Li
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2026-02-01
Серии:	Frontiers in Endocrinology
Предметы:	homozygosity medullary thyroid carcinoma monozygotic twins multiple endocrine neoplasia type 2 pheochromocytoma RET proto-oncogene
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fendo.2026.1690431/full
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