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The protective effect of doxofylline against lipopolysaccharides (LPS)-induced activation of NLRP3 inflammasome is mediated by SIRT1 in human pulmonary bronchial epithelial cells

Lung diseases are common health problems in many countries. The dysfunction of bronchial epithelial cells is important for the development of lung diseases. Recent progress reveals that inflammasome is the fundamental mechanism of epithelial activation. Here, we report the protective effect of doxof...

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Principais autores: Peng Jiao, Weiming Li, Lin Shen, Yan Li, Lili Yu, Zhaohui Liu
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2020-01-01
Serier:Artificial Cells, Nanomedicine, and Biotechnology
Fag:
Doxofylline
lipopolysaccharides (LPS)
NLRP3 inflammasome
SIRT1
bronchial epithelial cells
Online adgang:https://www.tandfonline.com/doi/10.1080/21691401.2020.1730391
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