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RIOK2 kinase regulates the translocation of the FADD–RIPK1–Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis

Abstract Macrophage infection by the pathogenic bacteria Yersinia or mimic stimulation of lipopolysaccharide (LPS) and transforming growth factor-β-activated kinase 1 (TAK1) inhibitor or tumor necrosis factor (TNF) and TAK1 inhibitor induces caspase-8-mediated gasdermin D (GSDMD) cleavage and pyropt...

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Main Authors: Mingtong Ma, Fei Wang, Pengfei Cui, Yingying Zhang, Hanyu Ma, Yifan He, Yuanna Cheng, Jingping Huang, Jingxiang Wang, Xiangyang Wu, Hua Yang, Ruijuan Zheng, Haowen Ma, Qian Cai, Lin Wang, Baoxue Ge
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2025-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-65012-7
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