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Meningitis-associated pneumococcal serotype 8, ST 53, strain is hypervirulent in a rat model and has non-haemolytic pneumolysin which can be attenuated by liposomes

IntroductionStreptococcus pneumoniae bacteria cause life-threatening invasive pneumococcal disease (IPD), including meningitis. Pneumococci are classified into serotypes, determined by differences in capsular polysaccharide and both serotype and pneumolysin toxin are associated with disease severity...

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Principais autores: Annelies Müller, Cebile Lekhuleni, Sabrina Hupp, Mignon du Plessis, Lalaina Holivololona, Eduard Babiychuk, Stephen L. Leib, Denis Grandgirard, Asparouh I. Iliev, Anne von Gottberg, Lucy J. Hathaway
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-01-01
coleção:Frontiers in Cellular and Infection Microbiology
Assuntos:
Streptococcus pneumoniae
meningitis
serotype 8
pneumolysin
liposomes
hyperviruent serotype 8
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcimb.2022.1106063/full
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