Design and Synthesis of Novel Aminoindazole-pyrrolo[2,3-<i>b</i>]pyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling

The inhibitory-kappaB kinases (IKKs) IKKα and IKKβ play central roles in regulating the non-canonical and canonical NF-κB signalling pathways. Whilst the proteins that transduce the signals of each pathway have been extensively characterised, the clear dissection of the functional roles of IKKα-medi...

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Autors principals:	Christopher Riley, Usama Ammar, Aisha Alsfouk, Nahoum G. Anthony, Jessica Baiget, Giacomo Berretta, David Breen, Judith Huggan, Christopher Lawson, Kathryn McIntosh, Robin Plevin, Colin J. Suckling, Louise C. Young, Andrew Paul, Simon P. Mackay
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2024-07-01
Col·lecció:	Molecules
Matèries:	inhibitory κB kinases IKKα nuclear factor-κB (NF-κB) non-canonical NF-κB signalling IKKα inhibitor
Accés en línia:	https://www.mdpi.com/1420-3049/29/15/3515
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