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Anti-Acinetobacter baumannii single-chain variable fragments provide therapeutic efficacy in an immunocompromised mouse pneumonia model

Abstract Background The emergence of carbapenem-resistant and extensively drug-resistant (XDR) Acinetobacter baumannii as well as inadequate effective antibiotics calls for an urgent effort to find new antibacterial agents. The therapeutic efficacy of two human scFvs, EB211 and EB279, showing growth...

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Principais autores: Eilnaz Basardeh, Somayeh Piri-Gavgani, Hamid Reza Moradi, Masoumeh Azizi, Parastoo Mirzabeigi, Farzaneh Nazari, Mostafa Ghanei, Fereidoun Mahboudi, Fatemeh Rahimi-Jamnani
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-02-01
Serier:BMC Microbiology
Fag:
Acinetobacter baumannii
Pneumonia
Immunotherapy
scFv
Bactericidal antibodies
Online adgang:https://doi.org/10.1186/s12866-023-03080-9
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