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Numb is required for optimal contraction of skeletal muscle

Abstract Background The role of Numb, a protein that is important for cell fate and development and that, in human muscle, is expressed at reduced levels with advanced age, was investigated; adult mice skeletal muscle and its localization and function within myofibres were determined. Methods Numb e...

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Principais autores: Rita De Gasperi, Chenglin Mo, Daniella Azulai, Zhiying Wang, Lauren M. Harlow, Yating Du, Zachary Graham, Jiangping Pan, Xin‐hua Liu, Lei Guo, Bin Zhang, Fred Ko, Ashleigh M. Raczkowski, William A. Bauman, Chris N. Goulbourne, Wei Zhao, Marco Brotto, Christopher P. Cardozo
Formato: Artigo
Idioma:Inglês
Publicado: Wiley 2022-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Assuntos:
Ageing
Sarcopenia
Excitation contraction coupling
Sarcomere
Mitochondria
Acceso en liña:https://doi.org/10.1002/jcsm.12907
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