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TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2

Abstract The reintegration of excised signal joints resulting from human V(D)J recombination was described as a potent source of genomic instability in human lymphoid cancers. However, such molecular events have not been recurrently reported in clinical patient lymphoma/leukemia samples. Using a spe...

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Principais autores: Estelle Balducci, Thomas Steimlé, Charlotte Smith, Patrick Villarese, Mélanie Feroul, Dominique Payet-Bornet, Sophie Kaltenbach, Lucile Couronné, Ludovic Lhermitte, Aurore Touzart, Marie-Emilie Dourthe, Mathieu Simonin, André Baruchel, Hervé Dombret, Norbert Ifrah, Nicolas Boissel, Bertrand Nadel, Elizabeth Macintyre, Agata Cieslak, Vahid Asnafi
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2023-07-01
coleção:Molecular Cancer
Assuntos:
T-cell receptor excision circles (TREC)
Oncogenesis
Cancer
Acesso em linha:https://doi.org/10.1186/s12943-023-01794-y
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