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Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children

Abstract Pediatric tuberculosis (TB) is challenging to diagnose, confirmed by growth of Mycobacterium tuberculosis at best in 40% of cases. The WHO has assigned high priority to the development of non-sputum diagnostic tools. We therefore sought to identify transcriptional signatures in whole blood...

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Autors principals: John Espen Gjøen, Synne Jenum, Dhanasekaran Sivakumaran, Aparna Mukherjee, Ragini Macaden, Sushil K. Kabra, Rakesh Lodha, Tom H. M. Ottenhoff, Marielle C. Haks, Timothy Mark Doherty, Christian Ritz, Harleen M. S. Grewal
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2017-07-01
Col·lecció:Scientific Reports
Accés en línia:https://doi.org/10.1038/s41598-017-05057-x
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