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Hirsutine, an Indole Alkaloid of Uncaria rhynchophylla, Inhibits Late Step in Dengue Virus Lifecycle

Dengue virus (DENV) is transmitted to humans by Aedes mosquitoes and is a public health issue worldwide. No antiviral drugs specific for treating dengue infection are currently available. To identify novel DENV inhibitors, we analyzed a library of 95 compounds and 120 extracts derived from crude dru...

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Principais autores: Takayuki Hishiki, Fumihiro Kato, Shigeru Tajima, Kazufumi Toume, Masahito Umezaki, Tomohiko Takasaki, Tomoyuki Miura
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-08-01
coleção:Frontiers in Microbiology
Assuntos:
dengue virus
antiviral
crude drug
herbal medicine
alkaloid
hirsutine
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01674/full
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