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Therapeutic potential of an anti-CCR9 mAb evidenced in xenografts of human CCR9+ tumors

Relapsed or refractory T acute lymphoblastic leukemia (T-ALL) still carries poor prognosis. Aiming to improve outcomes, the therapeutic potential of an anti-CCR9 monoclonal antibody (mAb 92R), targeting the human chemokine-receptor CCR9 is analyzed on orthotopic xenotransplants. 92R mAb treatment of...

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Principais autores: Silvia Santamaria, Marisa Delgado, Marta Botas, Eva Castellano, Isabel Corraliza-Gorjon, Paloma Lafuente, Cecilia Muñoz-Calleja, Maria L. Toribio, Leonor Kremer, Jose A. Garcia-Sanz
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-07-01
Serier:Frontiers in Immunology
Fag:
chemokine receptor CCR9
antitumoral activity
combined chemotherapy and immunotherapy
orthotopic xenograft mouse model
therapeutic antibodies
T-ALL leukemia
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.825635/full
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