Fusobacterium nucleatum-derived succinic acid aggravates colitis by triggering macrophage pro-inflammatory phenotypic transformation via SUCNR1/NF-κB axis

Fusobacterium nucleatum (F. nucleatum) has been increasingly implicated in the pathogenesis of inflammatory bowel disease (IBD), yet the mechanisms underlying its effects remain incompletely defined. In this study, we integrated human fecal and mucosal samples, comparative metabolomics, multiple exp...

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Autori principali:	Suqi Zeng, Shanshan Jiang, Jianxuan Sun, Yan Chen, Meiqi Qiu, Jiao Li, Qingzhi Lan, Yu Pu, Zongbiao Tan, Xingzhou Guo, Haodong He, Shuo Wang, Luyun Zhang, Yafei Liu, Jiaming Hu, Ruxue Wang, Fei Liao, Jixiang Zhang, Weiguo Dong
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis Group 2026-12-01
Serie:	Gut Microbes
Soggetti:	Inflammatory bowel disease Fusobacterium nucleatum succinic acid SUCNR1 macrophage NF-κB
Accesso online:	https://www.tandfonline.com/doi/10.1080/19490976.2026.2702183
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