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Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression.

We aimed to assess whether pri-miRNA SNPs (miSNPs) could influence monocyte gene expression, either through marginal association or by interacting with polymorphisms located in 3'UTR regions (3utrSNPs). We then conducted a genome-wide search for marginal miSNPs effects and pairwise miSNPs × 3utrSNPs...

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Principais autores: Nicolas Greliche, Tanja Zeller, Philipp S Wild, Maxime Rotival, Arne Schillert, Andreas Ziegler, Cardiogenics Consortium, Panos Deloukas, Jeanette Erdmann, Christian Hengstenberg, Willem H Ouwehand, Nilesh J Samani, Heribert Schunkert, Thomas Munzel, Karl J Lackner, François Cambien, Alison H Goodall, Laurence Tiret, Stefan Blankenberg, David-Alexandre Trégouët
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2012-01-01
coleção:PLoS ONE
Acesso em linha:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0045863&type=printable
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