Investigating the genetic association of mitochondrial DNA copy number with neurodegenerative diseases

Abstract Objective This study aims to investigate the causal relationship between Mitochondrial DNA (mtDNA) copy number and several common neurodegenerative diseases (NDs). Methods We conducted a bidirectional two-sample Mendelian randomization (MR) analysis using data from genome-wide association s...

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Detalhes bibliográficos

Principais autores:	Huan Xia, Zi-Hao Wang, Xiao-Bei Wang, Mei-Rong Gao, Sen Jiang, Xin-Yu Du, Xin-Ling Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-04-01
coleção:	BMC Neurology
Assuntos:	Neurodegenerative diseases Mitochondrial DNA copy number Mendelian randomization analysis Genome-wide association studies
Acesso em linha:	https://doi.org/10.1186/s12883-025-04176-7
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