Expanding the genetic toolkit: adenine and cytosine base editors for gene disruption in Aspergillus niger

Abstract Despite revolutionizing fungal genetic engineering, conventional CRISPR/Cas9-mediated knockouts rely on DNA double-strand breaks (DSBs), which can cause unwanted insertions and deletions, chromosomal abnormalities, and cytotoxicity. Base editors such as adenine base editors (ABEs), which co...

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Principais autores:	Guoliang Yuan, Shuang Deng, Ziyu Dai, Beth A. Hofstad, Kyle R. Pomraning
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2026-03-01
Serija:	Microbial Cell Factories
Teme:	CRIPSR Base editing Premature stop codon Intron retention Start codon mutation Aspergillus
Online dostop:	https://doi.org/10.1186/s12934-026-02979-y
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