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SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity

Abstract Chromatin remodeling complexes, such as the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex, play key roles in regulating gene expression by modulating nucleosome positioning. The core subunit SMARCB1 is essential for these functions, as it anchors the complex to the nucleosome acidic patc...

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Hoofdauteurs: Garrett W. Cooper, Benjamin P. Lee, Won Jun Kim, Yongdong Su, Victor Z. Chen, Eliseo Salas, Xiaoping Yang, Robert E. Lintner, Federica Piccioni, Andrew O. Giacomelli, Thomas P. Howard, Pritha Bagchi, Karen N. Conneely, David E. Root, Bo Liang, James C. Gumbart, William C. Hahn, David U. Gorkin, Jaclyn A. Biegel, Susan N. Chi, Andrew L. Hong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Portfolio 2026-04-01
Reeks:Nature Communications
Online toegang:https://doi.org/10.1038/s41467-026-71531-8
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