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Determination of Lekethromycin, a Novel Macrolide Lactone, in Rat Plasma by UPLC-MS/MS and Its Application to a Pharmacokinetic Study

Lekethromycin, a new macrolide lactone, exhibits significant antibacterial activity. In this study, a reliable analytical ultrahigh-performance liquid chromatography electrospray ionization quadrupole Orbitrap high-resolution mass spectrometry (UPLC-ESI-Orbitrap-MS) method was established and valida...

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Principais autores: Hongzhi Xiao, Pan Sun, Jicheng Qiu, Jianzhong Wang, Lei Yan, Suxia Zhang, Xingyuan Cao
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-10-01
Serier:Molecules
Fag:
UPLC-ESI-Orbitrap-MS
lekethromycin
rats
pharmacokinetic
Online adgang:https://www.mdpi.com/1420-3049/25/20/4676
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