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The bispecific B7H3xCD3 antibody CC-3 induces T cell immunity against bone and soft tissue sarcomas

Sarcomas are rare and heterogeneous malignancies that are difficult to treat. Approximately 50% of patients diagnosed with sarcoma develop metastatic disease with so far very limited treatment options. The transmembrane protein B7-H3 reportedly is expressed in various malignancies, including differe...

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Hauptverfasser: Samuel J. Holzmayer, Kai Liebel, Ilona Hagelstein, Helmut R. Salih, Melanie Märklin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2024-05-01
Schriftenreihe:Frontiers in Immunology
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Online-Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1391954/full
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