Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis.

Initial studies of 88 transmission pairs in the Zambia Emory HIV Research Project cohort demonstrated that the number of transmitted HLA-B associated polymorphisms in Gag, but not Nef, was negatively correlated to set point viral load (VL) in the newly infected partners. These results suggested that...

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Autores principales:	Jessica L Prince, Daniel T Claiborne, Jonathan M Carlson, Malinda Schaefer, Tianwei Yu, Shabir Lahki, Heather A Prentice, Ling Yue, Sundaram A Vishwanathan, William Kilembe, Paul Goepfert, Matthew A Price, Jill Gilmour, Joseph Mulenga, Paul Farmer, Cynthia A Derdeyn, Jiaming Tang, David Heckerman, Richard A Kaslow, Susan A Allen, Eric Hunter
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2012-01-01
Colección:	PLoS Pathogens
Acceso en línea:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003041&type=printable
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