Impact of the Warburg effect on nucleotide homeostasis in human retinal endothelial cells and its relevance to proliferative diabetic retinopathy

PurposeWhile great progress has been made in screening methods and therapies for proliferative diabetic retinopathy (PDR), it is still a major cause of blindness. Rapidly dividing cells reprogram their metabolism toward hyperglycolysis (the Warburg effect), a process recently implicated in angiogene...

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Principais autores:	Andrew Gregory, Ahmed M. Awad, Shaimaa Eltanani, Thangal Yumnamcha, Jenna Hart, Rao Me, Xihui Lin, Mohamed Shawky, Ahmed S. Ibrahim
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-11-01
coleção:	Frontiers in Pharmacology
Assuntos:	proliferative diabetic retinopathy (PDR) the Warburg effect nucleotide metabolism human retinal endothelial cells (HRECs) high glucose (HG) hypoxia (Hyp)
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1660067/full
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