FTO-engineered extracellular vesicles from bone marrow mesenchymal stem cells ameliorate Staphylococcus aureus-induced osteomyelitis via m6A-dependent suppression of autophagy and pyroptosis

Abstract Background Bone marrow mesenchymal stem cells (BM-MSCs) ameliorate various orthopedic diseases through the secretion of extracellular vesicles (EVs). This study investigates the effects of FTO-overexpressing BM-MSCs-derived EVs (FTO-EVs) on osteocyte autophagy and pyroptosis in Staphylococc...

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Detalhes bibliográficos
Main Authors: Muguo Song, Siyu Lu, Hao Tang, Kehan Lv, Junyi Li, Jian Shi, Yongqing Xu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-11-01
Colecção:Journal of Biological Engineering
Assuntos:
Mesenchymal stem cells
Staphylococcus aureus
Extracellular vesicle
Osteomyelitis
Autophagy
Pyroptotic cell death
Acesso em linha:https://doi.org/10.1186/s13036-025-00572-2
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