Sensitivity of Acute Myelocytic Leukemia Cells to the Dienone Compound VLX1570 Is Associated with Inhibition of the Ubiquitin-Proteasome System

Dienone compounds with a 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore have been widely reported to show tumor cell selectivity. These compounds target the ubiquitin-proteasome system (UPS), known to be essential for the viability of tumor cells. The induction of oxidative stress, depletion of glut...

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Egile Nagusiak:	Karthik Selvaraju, Kourosh Lotfi, Johannes Gubat, Maria Miquel, Amanda Nilsson, Julia Hill, Lasse D. Jensen, Stig Linder, Pádraig D’Arcy
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2021-09-01
Saila:	Biomolecules
Gaiak:	acute myeloid leukemia proteasome ubiquitin deubiquitinase zebrafish
Sarrera elektronikoa:	https://www.mdpi.com/2218-273X/11/9/1339
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