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The blood of healthy individuals exhibits CD8 T cells with a highly altered TCR Vb repertoire but with an unmodified phenotype.

CD8 T cell clonal expansions (TCE) have been observed in elderly, healthy individuals as well in old mice, and have been associated with the ageing process. Both chronic latent and non-persistent viral infections have been proposed to drive the development of distinct non-functional and functional T...

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Bibliografiske detaljer
Principais autores: Nicolas Degauque, Françoise Boeffard, Yohann Foucher, Caroline Ballet, Sophie Brouard, Jean-Paul Soulillou
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2011-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC3124488?pdf=render
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