Peripheral Autoimmune Regulator Induces Exhaustion of CD4+ and CD8+ Effector T Cells to Attenuate Autoimmune Diabetes in Non-Obese Diabetic Mice

Autoimmune regulator (Aire) is one of the most crucial genes expressed in the thymus, where it orchestrates the promiscuous expression and presentation of tissue-specific antigens during thymocyte selection. The presence of Aire-expressing cells outside the thymus points toward its plausible extrath...

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Bibliografiset tiedot

Päätekijät:	Divakar Kulshrestha, Li-Tzu Yeh, Ming-Wei Chien, Feng-Cheng Chou, Huey-Kang Sytwu
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Frontiers Media S.A. 2017-09-01
Sarja:	Frontiers in Immunology
Aiheet:	autoimmune regulator autoimmune diabetes dendritic cells T cell exhaustion effector T cells regulatory T cells
Linkit:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.01128/full
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