Exploration of T cell immune responses by expression of a dominant-negative SHP1 and SHP2

SHP1 and SHP2 are SH2 domain-containing proteins which have inhibitory phosphatase activity when recruited to phosphorylated ITIMs and ITSMs on inhibitory immune receptors. Consequently, SHP1 and SHP2 are key proteins in the transmission of inhibitory signals within T cells, constituting an importan...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Julia Taylor, Anna Bulek, Isaac Gannon, Mathew Robson, Evangelia Kokalaki, Thomas Grothier, Callum McKenzie, Mohamed El-Kholy, Maria Stavrou, Charlotte Traynor-White, Wen Chean Lim, Panagiota Panagiotou, Saket Srivastava, Vania Baldan, James Sillibourne, Mathieu Ferrari, Martin Pule, Simon Thomas
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2023-06-01
سلاسل:	Frontiers in Immunology
الموضوعات:	chimeric antigen receptor immunotherapy immunosuppression cancer cell engineering
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1119350/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!