VHL restoration in clear cell renal cell carcinoma improves NK cell infiltration and function
Abstract Background The von Hippel–Lindau (VHL) gene is frequently mutated in clear cell renal cell carcinoma (ccRCC) which results in stabilization of hypoxia-inducible factor (HIF). Despite the well-known immunosuppressive effect of HIF, ccRCC is considered an immunogenic tumor with high lymphocyt...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Springer
2025-07-01
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| Σειρά: | Cancer Immunology, Immunotherapy |
| Θέματα: | |
| Διαθέσιμο Online: | https://doi.org/10.1007/s00262-025-04132-x |
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