Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth.

Analogs and homologs of PDMP were synthesized, based on its structure (D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol). This compound had previously been found to block the synthesis of GlcCer (glucosylceramide). Increasing the acyl chain length from 10 to 16 carbon atoms greatly enhanced...

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Detalhes bibliográficos

Principais autores:	A Abe, N S Radin, J A Shayman, L L Wotring, R E Zipkin, R Sivakumar, J M Ruggieri, K G Carson, B Ganem
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 1995-03-01
coleção:	Journal of Lipid Research
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0022227520398953
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