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Regulatory T cell therapy for xenotransplantation, what perspectives?

Xenotransplantation has experienced major clinical advancements over the past three years. Yet, despite potent immunosuppressive regimens combining B-cell depleting therapies, T cell activation blockade, complement inhibition, and high-dose steroids, signs of antibody-mediated and cellular rejection...

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Principais autores: Raphaël Porret, Erica Lana, Antonio Mancarella, Philippe Guillaume, Manuel Pascual, Raphael P. H. Meier, Jonathan S. Bromberg, Muhammad M. Mohiuddin, Leo H. Buhler, Qizhi Tang, Yannick D. Muller
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2025-09-01
Series:Frontiers in Immunology
Assuntos:
xenotransplantation
xenograft tolerance
regulatory T cells
genetic engineering
chimeric antigen receptor
cell therapy
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1685682/full
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