Sustained mood improvement with laughing gas exposure (SMILE): a randomised, placebo-controlled pilot trial of nitrous oxide for treatment-resistant depression

Background Nitrous oxide may possess antidepressant effects; however, limited data exist on repeated administrations and active placebo-controlled studies in treatment-resistant depression (TRD). Aims We aimed to test the feasibility of a randomised controlled trial examining a 4-week course of...

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Principais autores:	Karim S. Ladha, Jiwon Lee, Gabriella F. Mattina, Janneth Pazmino-Canizares, Duminda N. Wijeysundera, Fatemeh Gholamali Nezhad, Vanessa K. Tassone, Fathima Adamsahib, Wendy Lou, Sidney Kennedy, Venkat Bhat
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cambridge University Press 2025-09-01
coleção:	BJPsych Open
Assuntos:	Treatment-resistant depression nitrous oxide randomised controlled trial RCT TRD
Acesso em linha:	https://www.cambridge.org/core/product/identifier/S2056472425108235/type/journal_article
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