Assessing the effect of genetic markers on drug immunogenicity from a mechanistic model-based approach

Abstract Background With the growth in use of biotherapic drugs in various medical fields, the occurrence of anti-drug antibodies represents nowadays a serious issue. This immune response against a drug can be due either to pre-existing antibodies or to the novel production of antibodies from B-cell...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Julianne Duhazé, Miguel Caubet, Signe Hässler, Delphine Bachelet, Matthieu Allez, Florian Deisenhammer, Anna Fogdell-Hahn, Aude Gleizes, Salima Hacein-Bey-Abina, Xavier Mariette, Marc Pallardy, Philippe Broët, on behalf of the ABIRISK Consortium
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-03-01
coleção:	BMC Medical Research Methodology
Assuntos:	Genetic Drug immunogenicity Semi-continuous data Two-part improper survival model Semi-parametric
Acesso em linha:	http://link.springer.com/article/10.1186/s12874-020-00941-z
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!