A Multicomponent Protocol for the Synthesis of Highly Functionalized γ-Lactam Derivatives and Their Applications as Antiproliferative Agents

An efficient synthetic methodology for the preparation of 3-amino 1,5-dihydro-2<i>H</i>-pyrrol-2-ones through a multicomponent reaction of amines, aldehydes, and pyruvate derivatives is reported. In addition, the densely substituted lactam substrates show in vitro cytotoxicity, inhibiting the growth...

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Principais autores:	Xabier del Corte, Adrián López-Francés, Aitor Maestro, Ilia Villate-Beitia, Myriam Sainz-Ramos, Edorta Martínez de Marigorta, José Luis Pedraz, Francisco Palacios, Javier Vicario
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-08-01
coleção:	Pharmaceuticals
Assuntos:	γ-lactams multicomponent synthesis antiproliferative effect
Acesso em linha:	https://www.mdpi.com/1424-8247/14/8/782
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