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Porcine Islet-Specific Tolerance Induced by the Combination of Anti-LFA-1 and Anti-CD154 mAbs is Dependent on PD-1

We previously demonstrated that short-term administration of a combination of anti-LFA-1 and anti-CD154 monoclonal antibodies (mAbs) induces tolerance to neonatal porcine islet (NPI) xenografts that is mediated by regulatory T cells (Tregs) in B6 mice. In this study, we examined whether the coinhibi...

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Autori principali: Hossein Arefanian, Eric B. Tredget, Dereck C. M. Mok, Qahir Ramji, Shahin Rafati, Jose Rodriguez-Barbosa, Gregory S. Korbutt, Ray V. Rajotte, Ron G. Gill, Gina R. Rayat
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE Publishing 2016-02-01
Serie:Cell Transplantation
Accesso online:https://doi.org/10.3727/096368915X688506
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